3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one, also known as p-Nitrostilbene, is a compound that has several applications in everyday life. It is commonly used in the manufacturing of dyes, pigments, and pharmaceuticals. Its unique chemical properties make it an important intermediate in the synthesis of various organic compounds. Additionally, p-Nitrostilbene is utilized in academic research as a model compound for studying chemical reactions and mechanisms. Overall, this compound plays a significant role in the chemical industry and contributes to advancements in various fields.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
The compound 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one, also known as p-nitrophenyl styryl ketone, has various commercial and industrial applications. It is commonly used as a substrate in organic synthesis reactions to introduce the styryl ketone functional group into compounds. This compound is also utilized as a fluorescent probe for sensing metal ions due to its unique spectral properties.
In the realm of drug and medication applications, 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one has shown potential as a pharmaceutical intermediate in the synthesis of various biologically active compounds. Researchers have investigated its role as a precursor in the development of new drugs for treating diseases such as cancer and Alzheimer’s. Additionally, this compound has been studied for its antimicrobial properties, highlighting its potential in the pharmaceutical industry.
⚗️ Chemical & Physical Properties
The chemical 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one is a yellow crystalline powder that has a slight, sweet odor. When handled, it leaves a faint aroma that can be identified by those familiar with organic compounds.
With a molar mass of approximately 263.24 g/mol and a density of 1.25 g/cm³, 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one is heavier and denser than common food items such as sugar and salt.
The compound has a melting point of 76-77°C and a boiling point of 318-319°C, which are significantly higher than those of common food items like butter and chocolate. This indicates that 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one is more stable at higher temperatures.
3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one is sparingly soluble in water but dissolves well in organic solvents. It has a low viscosity, similar to that of vegetable oil. This contrasts with common food items that exhibit higher solubility in water and can be more viscous in texture.
🏭 Production & Procurement
Production of 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one involves the condensation reaction of 4-nitrobenzaldehyde with acetophenone in the presence of a base catalyst. This reaction forms a yellow precipitate, which is then filtered and recrystallized to obtain the final product. The overall process requires careful attention to reaction conditions and purification steps to achieve high yields.
To procure 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one, one may contact chemical suppliers or manufacturers specializing in aromatic compounds. The compound can be purchased in bulk quantities or smaller amounts depending on the intended use. Proper documentation, such as a Material Safety Data Sheet (MSDS) and relevant permits, may be required for transportation and handling due to the compound’s potential hazards.
Transporting 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one should be done in accordance with regulations set forth by transportation authorities to ensure safety and compliance. The compound is typically shipped in sealed containers or drums, which are labeled with the necessary information and warnings. Care should be taken to prevent exposure to moisture, extreme temperatures, and incompatible substances during transit to maintain the integrity of the product.
⚠️ Safety Considerations
Safety considerations for 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one include the potential for skin and eye irritation upon contact. It is important to use appropriate personal protective equipment, such as gloves and goggles, when handling this compound. In addition, it is crucial to work in a well-ventilated area to prevent inhalation of any fumes or vapors.
The hazard statements for 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one include “Causes skin irritation” and “Causes serious eye irritation.” These statements indicate the potential for harm if the compound comes into contact with the skin or eyes. It is important to take necessary precautions to avoid direct skin or eye contact when working with this substance.
Precautionary statements for 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one include “Wear protective gloves/protective clothing/eye protection/face protection” and “Wash hands thoroughly after handling.” These statements emphasize the importance of using appropriate personal protective equipment and practicing good hygiene to minimize the risk of exposure and potential harm. It is crucial to follow these precautions to ensure safe handling of this compound.
🔬 Potential Research Directions
One potential research direction for 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one is the investigation of its potential biological activities. This compound shows promising potential as a pharmacological agent due to its structural features and nitrophenyl group. Understanding its interaction with biological systems could provide insights into its possible therapeutic applications.
Another avenue of research could involve the synthesis and study of analogs of 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one. By modifying the chemical structure of this compound, researchers can explore how different structural features affect its biological properties. This approach may lead to the development of more potent and selective derivatives with improved pharmacological profiles.
Furthermore, studying the mechanism of action of 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one could uncover novel insights into its biological effects. By elucidating how this compound interacts with its molecular targets and modulates cellular pathways, researchers can deepen their understanding of its pharmacological potential. This knowledge could pave the way for the rational design of new drugs targeting similar pathways.
🧪 Related Compounds
One similar compound to 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one based on molecular structure is 3-(4-Chlorophenyl)-1-phenylprop-2-en-1-one. This compound differs from the original in that the nitro group at the para position of the phenyl ring is replaced with a chlorine atom. This substitution not only changes the reactivity and properties of the compound but also alters its potential applications in various chemical reactions and synthetic processes.
Another compound similar in structure to 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one is 3-(4-Methylphenyl)-1-phenylprop-2-en-1-one. In this compound, the nitro group is replaced by a methyl group at the para position of the phenyl ring. This substitution results in differences in both physical and chemical properties compared to the original compound. The introduction of the methyl group may impact the compound’s solubility, stability, and reactivity in reactions involving nucleophilic or electrophilic species.
A third compound similar in structure to 3-(4-Nitrophenyl)-1-phenylprop-2-en-1-one is 3-(4-Hydroxyphenyl)-1-phenylprop-2-en-1-one. In this compound, the nitro group is substituted with a hydroxyl group at the para position of the phenyl ring. The presence of the hydroxyl group introduces new functional groups to the compound, thereby influencing its chemical reactivity and potential biological activities. This compound may exhibit different pharmacological properties or serve as a precursor for the synthesis of other compounds with specific applications in medicinal chemistry.
