2,2′-Bipyridine, a chemical compound primarily used in coordination chemistry, plays an important role in everyday life through its applications in various industries. Its ability to chelate metal ions makes it a valuable tool in catalysis, particularly in the production of pharmaceuticals, agrochemicals, and fine chemicals. Additionally, 2,2′-Bipyridine has been utilized in the development of materials for electronics, such as OLEDs, which are commonly found in smartphones and TVs. Furthermore, its role as a ligand in transition metal complexes has been studied for potential use in new technologies and materials. Overall, 2,2′-Bipyridine’s versatile properties contribute to advancements in various aspects of daily life, from healthcare to consumer electronics.
Table of Contents:
Commercial Applications
Chemical & Physical Properties
Production & Procurement
Safety Considerations
Potential Research Directions
Related Compounds
Commercial Applications
2,2′-Bipyridine, also known as bipyridine, is a heterocyclic compound that has various commercial and industrial applications. One of the main uses of 2,2′-Bipyridine is as a ligand in coordination chemistry, where it complexes with metal ions to form stable complexes. These complexes are utilized in catalysis, electrochemistry, and luminescence studies.
In the pharmaceutical industry, 2,2′-Bipyridine has found applications in drug development and medication. It is used as a building block in the synthesis of certain drugs, particularly in the development of anticancer compounds and antibiotics. The chemical structure of 2,2′-Bipyridine allows for modification and derivatization to create novel drug candidates with enhanced biological activities.
Additionally, 2,2′-Bipyridine is employed in the field of materials science for its properties as a molecular building block. It can be incorporated into supramolecular assemblies, polymers, and metal-organic frameworks to impart specific functionalities, such as luminescence or magnetic properties. These materials find applications in sensors, electronic devices, and catalytic processes.
Chemical & Physical Properties
2,2′-Bipyridine is a colorless crystalline solid with a characteristic musty odor. It is commonly used as a ligand in coordination chemistry due to its ability to chelate metal ions effectively.
The molar mass of 2,2′-Bipyridine is 156.19 g/mol, and it has a density of 1.03 g/cm3. In comparison to common household items, 2,2′-Bipyridine has a higher molar mass than water (18.015 g/mol) and a lower density than aluminum foil (2.70 g/cm3).
2,2′-Bipyridine has a melting point of 68-72°C and a boiling point of 244-247°C. These values are higher than those of water (melting point of 0°C and boiling point of 100°C) but lower than those of iron (melting point of 1538°C and boiling point of 2861°C).
2,2′-Bipyridine is sparingly soluble in water and exhibits low viscosity. In comparison to common household items, 2,2′-Bipyridine has lower solubility in water than salt, but higher viscosity than water.
Production & Procurement
2,2′-Bipyridine, also known as bipy, is typically produced through the oxidation of 2,2′-dipyridyl with nitric acid. This reaction results in the formation of 2,2′-Bipyridine along with water and nitrogen oxide as byproducts. The synthesis of 2,2′-Bipyridine requires careful control of temperature and reaction conditions to ensure high yield and purity.
Once produced, 2,2′-Bipyridine can be procured through various chemical suppliers and distributors. It is commonly available in both liquid and solid forms, depending on the intended use. The compound is typically packaged in sealed containers to prevent contamination and degradation during transportation. In terms of transportation, 2,2′-Bipyridine is classified as a hazardous material due to its flammable properties, and thus must be handled and shipped in compliance with relevant safety regulations.
Safety Considerations
Safety considerations for 2,2′-Bipyridine include the fact that it is flammable and may form explosive peroxides upon exposure to air. It can also cause irritation to the skin, eyes, and respiratory system upon contact or inhalation. When handling this chemical, it is important to wear appropriate personal protective equipment, such as gloves, goggles, and a lab coat, and to work in a well-ventilated area.
In terms of pharmacology, 2,2′-Bipyridine is a heterocyclic compound that is commonly used as a ligand in coordination chemistry. It forms stable complexes with metal ions, which can be utilized in various chemical reactions and catalytic processes. Due to its ability to chelate metal ions, 2,2′-Bipyridine has shown potential in applications such as organic synthesis, material science, and medicinal chemistry.
The hazard statements for 2,2′-Bipyridine include that it is harmful if swallowed, may cause skin and eye irritation, and is toxic to aquatic life. It is important to handle this chemical with care and to avoid releasing it into the environment. In case of exposure, seek medical attention immediately and follow established protocols for chemical spills and accidents.
Precautionary statements for 2,2′-Bipyridine include storing it in a cool, dry place away from heat sources and incompatible materials. It is important to use this chemical in a fume hood or well-ventilated area to prevent inhalation of vapors. When working with 2,2′-Bipyridine, be sure to follow all recommended safety practices and procedures to minimize the risk of accidents or exposure.
Potential Research Directions
One potential research direction for 2,2′-Bipyridine is the investigation of its coordination chemistry with various metal ions. This compound is known for its ability to form stable complexes with metals, which can have applications in catalysis, materials science, and medicinal chemistry.
Another possible avenue of study is exploring the use of 2,2′-Bipyridine as a building block in the design of supramolecular structures. By utilizing its unique structural features and ability to form strong intermolecular interactions, researchers can create complex assemblies with specific properties and functions, such as molecular recognition and self-assembly.
Furthermore, research into the electrochemical properties of 2,2′-Bipyridine and its derivatives could lead to the development of novel materials for applications in energy storage and conversion devices. Understanding the redox behavior of these compounds can provide insights into their potential as electroactive components in batteries, sensors, and other electrochemical devices.
Related Compounds
One similar compound to 2,2′-Bipyridine is 4,4′-Bipyridine. This compound has a similar molecular structure, with two pyridine rings connected at the 4 position instead of the 2 position. 4,4′-Bipyridine is also widely used in coordination chemistry as a ligand due to its ability to form stable complexes with metal ions.
Another related compound is 2,2′-Bithiazole. This compound consists of two thiazole rings connected at the 2 position, similar to how 2,2′-Bipyridine contains two pyridine rings connected at the 2 position. 2,2′-Bithiazole has been studied for its potential applications in organic electronics and materials science due to its unique structural and electronic properties.
A further similar compound is 2,2′-Bipyrimidine. This compound features two pyrimidine rings connected at the 2 position, similar to how 2,2′-Bipyridine contains two pyridine rings connected at the 2 position. 2,2′-Bipyrimidine has been investigated for its potential use in pharmaceuticals and materials science, given its structural similarities to 2,2′-Bipyridine and its potential for forming coordination complexes with metal ions.
