2-Pyridinecarboxaldehyde, also known as picolinic aldehyde, is a chemical compound with diverse applications in everyday life. This aldehyde is commonly utilized in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceuticals. Additionally, 2-Pyridinecarboxaldehyde is important in the production of pesticides, perfumes, and other organic compounds. Its wide array of uses highlights the significance of this compound in various aspects of our daily lives.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
2-Pyridinecarboxaldehyde, also known as pyridine-2-carbaldehyde, has several commercial and industrial applications. It is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and fragrances. The compound is also utilized in the production of dyes, polymers, and as a solvent in chemical reactions.
In terms of drug and medication applications, 2-Pyridinecarboxaldehyde is a key intermediate in the synthesis of pharmaceutical compounds. It is often used in the preparation of anti-inflammatory drugs, antibiotics, antifungal agents, and cardiovascular medications. The compound’s unique chemical properties make it a valuable component in the pharmaceutical industry for developing new therapeutic agents.
Furthermore, 2-Pyridinecarboxaldehyde has found utility in the field of medicinal chemistry for designing novel drug molecules. Its versatile nature allows for the creation of diverse chemical structures with potential pharmacological activity. Researchers continue to explore the potential of this compound in drug discovery and development, aiming to improve the treatment options available for various diseases and health conditions.
⚗️ Chemical & Physical Properties
2-Pyridinecarboxaldehyde is a colorless to pale yellow liquid with a strong, pungent odor reminiscent of almonds. This chemical compound is commonly used in the manufacturing of pharmaceuticals and agrochemicals due to its aromatic properties.
With a molar mass of 121.13 g/mol and a density of 1.08 g/cm³, 2-Pyridinecarboxaldehyde is heavier than common food items such as water (18.02 g/mol, 1 g/cm³) and sugar (342.30 g/mol, 1.59 g/cm³). This indicates that 2-Pyridinecarboxaldehyde is denser than water but lighter than sugar.
The melting point of 2-Pyridinecarboxaldehyde is 3°C, while its boiling point is 146°C. In comparison, common food items like butter have a melting point of approximately 32°C and a boiling point of 150-200°C. Therefore, 2-Pyridinecarboxaldehyde has a lower melting point but a slightly lower boiling point than butter.
2-Pyridinecarboxaldehyde is soluble in water and has a viscosity similar to that of ethanol. This contrasts with common food items like oil, which are not soluble in water and have a much higher viscosity. This makes 2-Pyridinecarboxaldehyde more easily dispersible in water compared to many food items.
🏭 Production & Procurement
2-Pyridinecarboxaldehyde, also known as picolinaldehyde, is typically produced through the oxidation of 2-methylpyridine. This oxidation reaction can be achieved using various methods, including the use of strong oxidizing agents such as chromic acid or potassium permanganate.
Once produced, 2-Pyridinecarboxaldehyde can be procured through chemical suppliers or specialty manufacturers. It is commonly available in both liquid and solid forms, depending on the specific requirements of the end user. The compound can be transported in sealed containers to prevent leakage and ensure safe handling during transit.
Transportation of 2-Pyridinecarboxaldehyde should adhere to local regulations and guidelines for the handling of hazardous materials. Proper labeling and documentation are essential to ensure the safe and secure transport of this chemical compound. It is recommended to work with experienced logistics partners to guarantee compliance with all necessary safety protocols.
⚠️ Safety Considerations
Safety Considerations for 2-Pyridinecarboxaldehyde:
2-Pyridinecarboxaldehyde, also known as pyridine-2-carboxaldehyde, should be handled with caution due to its potential hazards. This chemical compound is flammable and may ignite if exposed to heat or sparks. It is also harmful if swallowed, inhaled, or in contact with skin, as it can cause irritation or damage.
Additionally, 2-Pyridinecarboxaldehyde may be harmful to aquatic organisms if released into water sources. Therefore, proper measures should be taken to prevent this substance from entering the environment. It is advised to use personal protective equipment such as gloves, goggles, and a lab coat when working with this compound to minimize the risk of exposure.
Hazard Statements for 2-Pyridinecarboxaldehyde:
H226 – Flammable liquid and vapor.
H302 – Harmful if swallowed.
H315 – Causes skin irritation.
H319 – Causes serious eye irritation.
H332 – Harmful if inhaled.
H401 – Toxic to aquatic life.
Precautionary Statements for 2-Pyridinecarboxaldehyde:
P210 – Keep away from heat, sparks, open flames, and hot surfaces. No smoking.
P264 – Wash hands and exposed skin thoroughly after handling.
P280 – Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 – IF ON SKIN: Wash with plenty of soap and water.
P304+P340 – IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P501 – Dispose of contents/container in accordance with local/regional/national/international regulations.
🔬 Potential Research Directions
One potential research direction for 2-Pyridinecarboxaldehyde is its use as a pharmaceutical intermediate in the synthesis of various drugs and pharmaceutical compounds.
Additionally, research could explore the potential biological activities of 2-Pyridinecarboxaldehyde, such as its antimicrobial, antioxidant, or anti-inflammatory properties.
Another interesting research avenue could involve investigating the potential use of 2-Pyridinecarboxaldehyde in the field of materials science, such as its ability to act as a corrosion inhibitor or as a building block for novel polymers.
🧪 Related Compounds
One similar compound to 2-Pyridinecarboxaldehyde based upon its molecular structure is 4-Pyridinecarboxaldehyde. This compound shares the same pyridine ring structure as 2-Pyridinecarboxaldehyde but has the aldehyde group located at the 4-position on the ring. This structural similarity allows for similar reactivity and potential applications in organic synthesis.
Another related compound is Nicotinaldehyde, which is structurally similar to 2-Pyridinecarboxaldehyde due to its pyridine ring structure. However, Nicotinaldehyde differs in the placement of the aldehyde group, which is located at the 1-position on the pyridine ring. This slight structural variation can lead to differences in reactivity and potential biological activities compared to 2-Pyridinecarboxaldehyde.
Additionally, 3-Pyridinecarboxaldehyde is a compound that bears resemblance to 2-Pyridinecarboxaldehyde in terms of its molecular structure. The main difference lies in the position of the aldehyde group on the pyridine ring, which is situated at the 3-position in 3-Pyridinecarboxaldehyde. This structural similarity allows for potential overlapping reactivity and synthesis pathways between the two compounds.