2-Methylquinoline is a compound that is commonly used in the synthesis of pharmaceuticals, dyes, and agrochemicals. It plays a crucial role in the development of various medications, such as antimalarial and anticancer drugs. Additionally, 2-Methylquinoline is also used in the production of fragrances and flavorings, making it a key component in a wide range of consumer products. Its versatility and importance in various industries highlight its relevance to everyday life, as it contributes to the creation of essential goods and innovations that impact society at large.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
2-Methylquinoline, a derivative of quinoline, has various commercial and industrial applications. It is primarily used in the production of dyes, pigments, and pharmaceuticals. Its unique chemical properties make it a valuable intermediate in the synthesis of various fine chemicals.
In the realm of drug and medication applications, 2-Methylquinoline has shown promise as a potential antitumor agent. Research studies have highlighted its ability to inhibit cell growth and induce apoptosis in cancer cells. This has sparked interest in further exploring its therapeutic potential in the treatment of various types of cancer.
Furthermore, 2-Methylquinoline has also been investigated for its antimalarial properties. Studies have demonstrated its efficacy in inhibiting the growth of the Plasmodium falciparum parasite, which is responsible for causing malaria. This has raised the possibility of utilizing 2-Methylquinoline in the development of novel antimalarial drugs.
⚗️ Chemical & Physical Properties
2-Methylquinoline is a colorless to pale yellow liquid with a faint odor. It is a heterocyclic compound that is commonly used in the manufacturing of dyes and pharmaceuticals.
The molar mass of 2-Methylquinoline is 143.19 g/mol and its density is 1.090 g/cm³. Compared to common food items such as sugar (molar mass around 342.3 g/mol) and olive oil (density around 0.92 g/cm³), 2-Methylquinoline has a lower molar mass and higher density.
2-Methylquinoline has a melting point of -22°C and a boiling point of 243°C. Compared to common food items like butter (melting point around 32°C) and water (boiling point around 100°C), 2-Methylquinoline has a lower melting point and higher boiling point.
2-Methylquinoline is sparingly soluble in water and has a low viscosity. Compared to common food items like salt (high solubility in water) and honey (high viscosity), 2-Methylquinoline has poor solubility in water and low viscosity.
🏭 Production & Procurement
2-Methylquinoline is typically produced through a Friedländer quinoline synthesis reaction. This involves the condensation of aniline and a ketone, such as acetone, in the presence of sulfuric acid or other acid catalysts.
The procurement of 2-Methylquinoline can be done through chemical suppliers or pharmaceutical companies that specialize in fine chemicals. It is typically available in various purities and quantities to meet the needs of different industries.
Once procured, 2-Methylquinoline can be transported in sealed containers to prevent contamination or degradation. It is important to follow proper handling and storage procedures to ensure the quality and integrity of the compound during transit.
⚠️ Safety Considerations
Safety considerations for 2-Methylquinoline include its flammability and potential for causing skin and eye irritation. When handling this chemical, it is important to wear appropriate personal protective equipment, such as gloves and safety goggles, to prevent contact with the skin or eyes. In addition, 2-Methylquinoline should be stored in a cool, well-ventilated area away from sources of ignition to reduce the risk of fire or explosion.
Hazard statements for 2-Methylquinoline include “Causes skin irritation” and “Causes serious eye irritation.” These statements indicate that exposure to this chemical can result in irritation to the skin and eyes, which may require medical attention. It is important to take precautions when working with 2-Methylquinoline to prevent contact with the skin or eyes and to seek medical assistance if exposure occurs.
Precautionary statements for 2-Methylquinoline include “Wear protective gloves/protective clothing/eye protection/face protection” and “IF IN EYES: Rinse cautiously with water for several minutes.” These statements highlight the importance of wearing appropriate personal protective equipment when working with this chemical and the necessary steps to take in case of eye exposure. Following these precautions can help minimize the risks associated with handling 2-Methylquinoline and ensure a safe working environment.
🔬 Potential Research Directions
One potential research direction for 2-Methylquinoline is its role in pharmacology as a building block for potential drug molecules. By modifying the structure of 2-Methylquinoline, researchers can explore its potential as a drug candidate for various therapeutic applications.
Another potential research direction for 2-Methylquinoline is in the field of organic chemistry, where it can serve as a versatile starting material for the synthesis of complex molecules. By utilizing 2-Methylquinoline as a key intermediate, researchers can develop new methodologies for the construction of diverse chemical structures with potential pharmaceutical or material applications.
Furthermore, investigation into the environmental impact of 2-Methylquinoline and its derivatives could shed light on their potential toxicity and persistence in the environment. Understanding the fate and behavior of 2-Methylquinoline compounds in natural systems can inform strategies for their safe handling and disposal in industrial settings.
🧪 Related Compounds
One similar compound to 2-Methylquinoline is 2-Ethylquinoline. This compound has a similar molecular structure to 2-Methylquinoline, but with an ethyl group (C2H5) attached to the quinoline ring instead of a methyl group. This subtle difference results in 2-Ethylquinoline having slightly different physical and chemical properties compared to 2-Methylquinoline.
Another compound with a molecular structure akin to 2-Methylquinoline is 2-Isopropylquinoline. In this compound, an isopropyl group (-CH(CH3)2) is attached to the quinoline ring, replacing the methyl group found in 2-Methylquinoline. This substitution alters the steric and electronic properties of the compound, impacting its reactivity and biological activity relative to 2-Methylquinoline.
A further related compound is 2-Phenylquinoline, featuring a phenyl group (C6H5) in place of the methyl group in 2-Methylquinoline. This alteration results in a compound with distinct physical and chemical properties compared to 2-Methylquinoline, such as different solubility, melting point, and biological activity. The presence of the phenyl group can also influence the compound’s interactions with other molecules and receptors in biological systems.
