2-Hydroxybenzonitrile 

2-Hydroxybenzonitrile is a chemical compound that has relevance in everyday life due to its use in various industries and applications. It is commonly used as a precursor in the synthesis of pharmaceuticals, pesticides, and organic compounds. Additionally, 2-Hydroxybenzonitrile is utilized in the production of dyes, perfumes, and flavoring agents. Its properties make it a valuable component in the manufacturing processes of numerous household products, contributing to its significance in everyday life.

Table of Contents:

• 💡  Commercial Applications
• ⚗️  Chemical & Physical Properties
• 🏭  Production & Procurement
• ⚠️  Safety Considerations
• 🔬  Potential Research Directions
• 🧪  Related Compounds

💡  Commercial Applications

2-Hydroxybenzonitrile, also known as salicylonitrile, is a compound that has various commercial and industrial applications. It is commonly used as an intermediate in the production of pharmaceuticals, dyes, perfumes, and agricultural chemicals. Additionally, 2-Hydroxybenzonitrile is utilized in the manufacturing of metal surface treatments and as a corrosion inhibitor in industrial processes.

In terms of drug and medication applications, 2-Hydroxybenzonitrile is a key precursor in the synthesis of salicylamide, which is a non-prescription drug used to relieve pain and reduce fever. Furthermore, this compound has shown potential as a building block for the production of new anti-inflammatory medications. Due to its ability to inhibit certain enzymes involved in inflammatory responses, 2-Hydroxybenzonitrile holds promise for the development of novel pharmaceuticals in the treatment of various diseases.

⚗️  Chemical & Physical Properties

2-Hydroxybenzonitrile, also known as salicylonitrile, presents itself as a white crystalline solid with no distinct odor. It possesses a slightly bitter taste, similar to certain pharmaceuticals.

With a molar mass of 137.14 g/mol and a density of approximately 1.21 g/cm^3, 2-Hydroxybenzonitrile falls within the range of molar masses and densities commonly found in food items such as sugars and proteins.

The compound exhibits a melting point of around 114-116°C and a boiling point of 290°C, which are notably higher than those of most common food items. This characteristic can be attributed to the aromatic nature of the compound.

2-Hydroxybenzonitrile is sparingly soluble in water but dissolves readily in organic solvents. It exhibits a relatively low viscosity, which contrasts with the thicker consistency often observed in certain food items like oils and syrups.

🏭  Production & Procurement

2-Hydroxybenzonitrile, also known as salicylonitrile, is typically produced through a reaction between salicylic acid and phosphorus trichloride in the presence of triethylamine. This reaction results in the formation of a complex mixture of products, which can be separated and purified to obtain the desired 2-Hydroxybenzonitrile.

Once produced, 2-Hydroxybenzonitrile can be procured through commercial suppliers who specialize in chemical compounds. It is commonly available in bulk quantities and can be purchased in various forms, such as powder or liquid. The compound can be transported using standard chemical handling procedures to ensure its integrity and safety during transit.

Alternatively, 2-Hydroxybenzonitrile can also be synthesized in the laboratory by experienced chemists using the appropriate reagents and equipment. This method allows for greater control over the purity and yield of the compound, making it suitable for research and development purposes. Regardless of the method of procurement, proper handling and storage of 2-Hydroxybenzonitrile are essential to prevent degradation and ensure its efficacy in various chemical reactions.

⚠️  Safety Considerations

Safety Considerations for 2-Hydroxybenzonitrile:

2-Hydroxybenzonitrile, also known as salicylonitrile, is a chemical compound commonly used in the synthesis of pharmaceuticals and dye intermediates. Safety considerations for handling this compound include its potential for irritation to the skin, eyes, and respiratory tract. It is important to wear appropriate personal protective equipment such as gloves, goggles, and a lab coat when working with 2-Hydroxybenzonitrile to minimize exposure.

In addition, due to its potential flammability, 2-Hydroxybenzonitrile should be stored in a cool, well-ventilated area away from sources of heat or flames. It is also important to avoid ingestion or inhalation of this compound, as it may cause harm to internal organs and respiratory system. Proper safety protocols should be followed when handling 2-Hydroxybenzonitrile to ensure the well-being of laboratory personnel.

Hazard Statements for 2-Hydroxybenzonitrile:

Hazard statements for 2-Hydroxybenzonitrile include “Causes skin irritation,” “Causes serious eye irritation,” and “May cause respiratory irritation.” These statements indicate the potential risks associated with exposure to this compound, highlighting the importance of using appropriate protective measures when working with 2-Hydroxybenzonitrile. It is crucial to follow safety guidelines and protocols to minimize the likelihood of harm from these hazards.

Precautionary Statements for 2-Hydroxybenzonitrile:

Precautionary statements for 2-Hydroxybenzonitrile include “Wear protective gloves/eye protection/face protection,” “IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing,” and “IF INHALED: Remove person to fresh air and keep comfortable for breathing.” These statements emphasize the importance of using personal protective equipment, following proper handling procedures, and seeking medical attention in case of exposure to 2-Hydroxybenzonitrile. Adhering to these precautions can help reduce the risk of adverse effects and ensure safe handling of this compound.

🔬  Potential Research Directions

Research on 2-Hydroxybenzonitrile, an aromatic compound, has the potential to explore its diverse uses in various fields. One potential research direction is the synthesis of novel derivatives with improved properties for pharmaceutical applications. Understanding the structure-activity relationship of these derivatives could lead to the development of more effective drugs.

Another avenue of research could focus on the environmental impact of 2-Hydroxybenzonitrile and its derivatives. Studies could investigate the biodegradability and toxicity of these compounds, shedding light on their potential risks and benefits in the ecosystem. By exploring these aspects, researchers can contribute to the development of sustainable practices for their synthesis and disposal.

🧪  Related Compounds

One similar compound to 2-Hydroxybenzonitrile based on molecular structure is 3-Hydroxybenzonitrile. This compound has a hydroxyl group at the para position relative to the nitrile group. The presence of the hydroxyl group can impart similar chemical properties to 2-Hydroxybenzonitrile, making them comparable in terms of reactivity and potential applications in various reactions.

Another compound with a similar molecular structure is 4-Hydroxybenzonitrile. This compound also features a hydroxyl group adjacent to the nitrile group, albeit in a different position compared to 2-Hydroxybenzonitrile. The close proximity of the hydroxyl and nitrile groups in both compounds can lead to similar interactions with other molecules and similar biological activities, if present.

Additionally, 2,3-Dihydroxybenzonitrile can be considered a similar compound to 2-Hydroxybenzonitrile based on molecular structure. This compound possesses two hydroxyl groups on the benzene ring, one of which is in the ortho position to the nitrile group. The presence of multiple hydroxyl groups can alter the compound’s reactivity and potential applications in comparison to 2-Hydroxybenzonitrile, despite similarities in their molecular structures.