2-Fluorobenzoyl chloride, a chemical compound used primarily in organic synthesis, has significant relevance to everyday life due to its role in the production of various pharmaceuticals, agrochemicals, and materials. This compound serves as a key building block in the creation of essential products such as medicines, pesticides, and specialized polymers. Its versatility and importance in numerous industries highlight its impact on daily life, despite it being commonly overlooked by the general public.
Table of Contents:
Commercial Applications
Chemical & Physical Properties
Production & Procurement
Safety Considerations
Potential Research Directions
Related Compounds
Commercial Applications
2-Fluorobenzoyl chloride, also known as o-fluorobenzoyl chloride, is primarily used in commercial and industrial applications as a key intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. This compound serves as a valuable building block for the production of materials with high economic value due to its versatile chemical properties.
In the realm of drug and medication applications, 2-Fluorobenzoyl chloride plays a crucial role in the pharmaceutical industry as a precursor for the synthesis of a wide range of pharmaceutical compounds. This compound is utilized in the creation of active pharmaceutical ingredients (APIs) that are incorporated into various medications for the treatment of diverse health conditions. The unique molecular structure of 2-Fluorobenzoyl chloride enables the development of novel drug formulations with enhanced therapeutic properties.
Overall, the commercial and industrial applications of 2-Fluorobenzoyl chloride are vast and diverse, making it a valuable chemical compound in the fields of pharmaceuticals, agrochemicals, and materials science. Its versatile reactivity and functional group compatibility have established its significance as a key intermediate in the synthesis of advanced materials with potential applications in various industries.
Chemical & Physical Properties
2-Fluorobenzoyl chloride is a white to pale yellow solid with a pungent odor. It is a chemical compound commonly used in organic synthesis and as a reagent in laboratory reactions.
The molar mass of 2-Fluorobenzoyl chloride is approximately 158.56 g/mol, and its density is around 1.224 g/cm³. In comparison to common food items, such as sugar with a molar mass of 342.3 g/mol and density of 1.59 g/cm³, 2-Fluorobenzoyl chloride is lighter in molar mass and density.
The melting point of 2-Fluorobenzoyl chloride is typically between 28-30°C, while the boiling point ranges from 279-280°C. Compared to common food items like butter with a melting point of around 32-35°C and water with a boiling point of 100°C, 2-Fluorobenzoyl chloride has a lower melting point and higher boiling point.
2-Fluorobenzoyl chloride is sparingly soluble in water and has a low viscosity. In contrast, common food items like sugar and salt are highly soluble in water, and honey has higher viscosity.
Production & Procurement
In the realm of organic chemistry, the production of 2-Fluorobenzoyl chloride is generally carried out through a multi-step synthetic process. One common method involves reacting 2-fluorobenzoic acid with thionyl chloride, resulting in the desired product. This process typically requires careful control of reaction conditions and purification steps to obtain high yields of 2-Fluorobenzoyl chloride.
Procuring 2-Fluorobenzoyl chloride for research or industrial purposes can be accomplished through various chemical suppliers and manufacturers. This compound is typically available in either liquid or solid form, depending on the specific requirements of the end user. Transportation of 2-Fluorobenzoyl chloride typically follows standard regulations for handling hazardous chemicals and may involve specialized packaging and labeling to ensure safe delivery.
When procuring 2-Fluorobenzoyl chloride, it is important to consider the potential hazards associated with this compound. Due to its reactive nature and potential for causing skin irritation and respiratory issues, proper handling procedures and personal protective equipment are recommended when working with 2-Fluorobenzoyl chloride. Additionally, storage of this compound should be in a well-ventilated area away from sources of ignition to minimize any potential risks.
Safety Considerations
Safety considerations for 2-Fluorobenzoyl chloride include its flammability and potential for causing skin and eye irritation upon contact. It is important to handle this compound with caution and wear appropriate personal protective equipment, such as gloves and goggles, to prevent accidental exposure. Additionally, proper ventilation should be ensured when working with 2-Fluorobenzoyl chloride to avoid inhaling harmful vapors.
Hazard statements for 2-Fluorobenzoyl chloride include “Causes severe skin burns and eye damage” and “May cause respiratory irritation.” These statements highlight the potential dangers associated with exposure to this compound, emphasizing the importance of following safe handling procedures and utilizing protective measures to minimize risks. It is crucial to be aware of these hazards when working with 2-Fluorobenzoyl chloride to prevent accidents and ensure personal safety.
Precautionary statements for 2-Fluorobenzoyl chloride recommend using protective gloves, eye protection, and face protection when handling this compound to prevent skin and eye irritation. It is also advised to work in a well-ventilated area or use respiratory protection to avoid breathing in harmful vapors. In case of skin contact, immediate removal of contaminated clothing and thorough washing of the affected area with soap and water is recommended, while in case of eye contact, rinsing eyes with water for several minutes is necessary. Following these precautionary measures is essential to ensure safe handling of 2-Fluorobenzoyl chloride and minimize the risk of accidents or injuries.
Potential Research Directions
One potential research direction for 2-Fluorobenzoyl chloride involves exploring its use as a reagent in organic synthesis to introduce a fluorine atom into aromatic compounds. This can lead to the development of new pharmaceuticals, agrochemicals, and materials with improved properties.
Another area of interest could be investigating the reactivity of 2-Fluorobenzoyl chloride with various nucleophiles to understand its potential for forming new carbon-carbon or carbon-heteroatom bonds. This research can contribute to the expansion of the chemical toolbox available to synthetic chemists for creating complex molecules in a more efficient and sustainable manner.
Related Compounds
One similar compound to 2-Fluorobenzoyl chloride is 4-Fluorobenzoyl chloride. This compound has a similar molecular structure to 2-Fluorobenzoyl chloride, with a fluoro group attached to the benzoyl chloride functional group at the para position instead of the ortho position.
Another similar compound is 3-Fluorobenzoyl chloride. Like 2-Fluorobenzoyl chloride, this compound has a fluoro group attached to the benzoyl chloride functional group. However, in this case, the fluoro group is located at the meta position on the benzene ring.
Additionally, 2-Chlorobenzoyl chloride is another compound with a similar molecular structure to 2-Fluorobenzoyl chloride. In this compound, a chlorine atom is attached to the benzoyl chloride functional group in the ortho position, instead of a fluorine atom as in 2-Fluorobenzoyl chloride.
