2′-Chloroacetoacetanilide, also known as Clorindione, is a compound that has garnered attention in the scientific community for its potential applications in pharmaceuticals. Specifically, research has shown that this compound possesses anti-inflammatory and analgesic properties, making it a promising candidate for the development of drugs for pain relief. As such, the relevance of 2′-Chloroacetoacetanilide to everyday life lies in its potential to contribute to the development of new and improved medications that could help alleviate pain and improve quality of life for individuals suffering from various health conditions.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
2′-Chloroacetoacetanilide, also known as Dichlofenac, has various commercial and industrial applications. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Additionally, it is utilized in the production of dyes and pigments, as well as in the manufacturing of other specialty chemicals.
In the realm of drug and medication applications, 2′-Chloroacetoacetanilide has been widely utilized as an anti-inflammatory agent. It is a key component in several nonsteroidal anti-inflammatory drugs (NSAIDs) which are commonly used to treat pain and inflammation associated with various conditions such as arthritis and muscle injuries. Additionally, it has shown promise in the treatment of migraines and other types of acute pain.
The commercial and industrial significance of 2′-Chloroacetoacetanilide cannot be overstated, as it serves as a crucial building block in the synthesis of a wide range of compounds. In the pharmaceutical industry, it is used to create drugs that alleviate pain, reduce inflammation, and improve the quality of life for millions of individuals worldwide. Its versatility and efficacy make it an indispensable ingredient in the production of various products that benefit society as a whole.
⚗️ Chemical & Physical Properties
2′-Chloroacetoacetanilide appears as a white crystalline solid with a faint odor. Its physical appearance is comparable to powdered sugar, but its odor is much less pronounced compared to common food items.
With a molar mass of approximately 221.67 g/mol and a density of around 1.4 g/cm3, 2′-Chloroacetoacetanilide is heavier than most common food items. For example, sugar has a molar mass of 342.3 g/mol and a density of 1.59 g/cm3, making it heavier and more dense than 2′-Chloroacetoacetanilide.
2′-Chloroacetoacetanilide has a melting point of around 162°C and a boiling point of approximately 468°C. In comparison, common food items such as sugar have melting and boiling points much lower than that of 2′-Chloroacetoacetanilide. For instance, sugar melts at around 186°C and boils at approximately 180°C.
This compound is sparingly soluble in water, and exhibits a low viscosity. In contrast, common food items like salt exhibit high solubility in water and have higher viscosity compared to 2′-Chloroacetoacetanilide.
🏭 Production & Procurement
Producing 2′-Chloroacetoacetanilide involves the reaction of 2-chloroacetyl chloride with acetanilide, resulting in the formation of the desired compound. This reaction typically takes place in the presence of a suitable base and solvent, under controlled conditions to ensure the desired product is obtained.
Once 2′-Chloroacetoacetanilide is produced, it can be procured through various chemical supply companies that specialize in the distribution of fine chemicals and intermediates. The compound can be transported in sealed containers to prevent any contamination or degradation during transit, and it should be handled with care to avoid exposure to moisture or other reactive substances.
Another common method of procuring 2′-Chloroacetoacetanilide is through custom synthesis from a reputable contract manufacturing organization. This allows for the compound to be produced to specific purity and quality standards, tailored to the customer’s requirements. The synthesized product can then be shipped in appropriate packaging, following all necessary regulations for the transport of hazardous chemicals.
⚠️ Safety Considerations
Safety considerations for 2′-Chloroacetoacetanilide should be taken seriously due to its potential hazards. The compound is a skin and eye irritant and may cause respiratory irritation if inhaled. It is also harmful if swallowed, leading to gastrointestinal irritation, nausea, vomiting, and diarrhea. Personal protective equipment, such as gloves, goggles, and a mask, should be worn when handling this compound to minimize the risk of exposure.
Hazard statements for 2′-Chloroacetoacetanilide include “Causes skin irritation,” “Causes serious eye irritation,” and “Harmful if swallowed.” These statements highlight the potential dangers associated with the compound and emphasize the importance of taking necessary precautions when working with it. It is essential to follow proper safety protocols to prevent any adverse effects on human health.
Precautionary statements for 2′-Chloroacetoacetanilide include “Avoid breathing dust/fume/gas/mist/vapors/spray,” “Wear protective gloves/protective clothing/eye protection/face protection,” and “IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.” These statements provide guidelines on how to safely handle the compound, stressing the importance of avoiding inhalation, wearing appropriate protective gear, and knowing what to do in case of ingestion. Adhering to these precautionary measures is crucial in ensuring the well-being of individuals working with 2′-Chloroacetoacetanilide.
🔬 Potential Research Directions
One potential research direction for 2′-Chloroacetoacetanilide is exploring its pharmacological properties and potential applications in drug development. Studies could focus on its biological activity, mechanism of action, and potential therapeutic uses in treating various medical conditions.
Another area of research could involve investigating the synthesis and structural modifications of 2′-Chloroacetoacetanilide to enhance its stability, solubility, and bioavailability. By exploring different synthetic routes and chemical modifications, researchers may discover new derivatives with improved pharmaceutical properties that could lead to the development of novel drugs with enhanced efficacy and reduced side effects.
🧪 Related Compounds
One similar compound to 2′-Chloroacetoacetanilide is 2′-Bromoacetoacetanilide. This compound has a structure very similar to 2′-Chloroacetoacetanilide, with the chlorine atom being replaced by a bromine atom. This substitution results in a compound with similar chemical properties, but with some differences in reactivity that may be of interest in certain applications.
Another related compound is 2′-Nitroacetoacetanilide. In this compound, the chlorine atom is replaced with a nitro group, altering the electronic properties of the molecule. This substitution may result in changes in reactivity and biological activity compared to 2′-Chloroacetoacetanilide, making 2′-Nitroacetoacetanilide a compound worthy of further study.
Additionally, 2′-Methoxyacetoacetanilide is another similar compound to 2′-Chloroacetoacetanilide. In this compound, the chlorine atom is replaced with a methoxy group, introducing a new functional group to the molecule. This substitution can lead to differences in solubility, reactivity, and biological activity compared to 2′-Chloroacetoacetanilide, making 2′-Methoxyacetoacetanilide a compound with its own unique properties.
