2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid, also known as Levothyroxine, is a synthetic form of thyroid hormone that is commonly used to treat hypothyroidism. This medication is crucial in regulating metabolism, energy levels, and overall bodily functions. Its relevance in everyday life lies in its ability to alleviate symptoms associated with an underactive thyroid gland, such as fatigue, weight gain, and depression, allowing individuals to lead a more productive and fulfilling life.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
The compound 2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid, also known as iopamidol, has various commercial and industrial applications. One of its primary uses is as a contrast agent in medical imaging procedures such as X-rays, CT scans, and angiography. Its ability to absorb X-rays and enhance the visibility of specific organs or blood vessels makes it invaluable in diagnostic medicine. Additionally, iopamidol is used in research settings to study the distribution of fluids and organs within the body.
In the realm of drug and medication applications, iopamidol plays a crucial role as a radiopaque contrast agent. It is commonly used in the imaging of various body structures to aid in the diagnosis of conditions such as vascular disease, tumors, and urinary tract disorders. In addition to its diagnostic utility, iopamidol is also utilized during therapeutic procedures such as endovascular surgeries and radiofrequency ablation. Its inert properties and low toxicity make it a safe and effective option for medical professionals seeking to improve the visibility of internal structures during procedures.
⚗️ Chemical & Physical Properties
2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid is a white crystalline solid that is odorless. It typically appears as fine particles or flakes.
The molar mass of 2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid is approximately 427.02 g/mol, with a density of about 3.34 g/cm³. When compared to common food items, such as sugar (342.3 g/mol, 1.59 g/cm³) and salt (58.44 g/mol, 2.17 g/cm³), this compound has a higher molar mass and density.
The melting point of 2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid is around 202-204°C, with a boiling point of approximately 584°C. In comparison, common food items like butter (melting point 32-35°C, boiling point 150-200°C) and honey (melting point 31-36°C, boiling point 115-130°C) have significantly lower melting and boiling points.
2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid is sparingly soluble in water and has a low viscosity. This is in contrast to common food items like sugar and salt, which are readily soluble in water and have a higher viscosity.
🏭 Production & Procurement
2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid is typically produced through a series of chemical synthesis steps. The starting materials for this process include 4-hydroxy-3,5-diiodophenylacetic acid and L-alanine. These compounds are reacted together under specific conditions to form the desired product.
Once 2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid is produced, it can be procured through various chemical suppliers or pharmaceutical companies. The compound is typically sold in its pure form as a white crystalline solid. It is important to ensure that the material is handled and transported in accordance with safety guidelines to prevent any potential hazards.
In order to transport 2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid, proper packaging and labeling are essential. The compound should be packaged in suitable containers that prevent any spillage or contamination during transportation. Additionally, shipping regulations must be followed to ensure compliance with safety standards.
⚠️ Safety Considerations
Safety considerations for 2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid include the potential for skin irritation, eye irritation, and respiratory irritation upon exposure. It is important to handle this compound with caution, wearing appropriate personal protective equipment such as gloves, goggles, and a lab coat. Additionally, ensure proper ventilation in the area where this compound is being used to prevent inhalation of potentially harmful vapors.
Hazard statements for 2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid include “Causes skin irritation,” “Causes serious eye irritation,” and “May cause respiratory irritation.” It is important to handle this compound with care to minimize the risk of these hazards. Proper safety precautions should be taken when working with this compound, including the use of appropriate personal protective equipment and working in a well-ventilated area.
Precautionary statements for 2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid include “Wear protective gloves/eye protection/face protection,” “IF ON SKIN: Wash with plenty of soap and water,” and “IF IN EYES: Rinse cautiously with water for several minutes.” It is important to follow these precautionary statements carefully to ensure safe handling of this compound. In case of accidental exposure, it is crucial to seek medical advice immediately and provide the relevant information about the compound to healthcare professionals.
🔬 Potential Research Directions
One potential research direction for 2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid could involve exploring its pharmacological properties, specifically its potential as a drug candidate for treating thyroid disorders. Researchers could investigate its mechanism of action, pharmacokinetics, and potential side effects to determine its efficacy and safety for clinical use.
Another avenue of research could focus on the synthesis and modification of 2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid derivatives to improve its bioavailability and potency. By altering the chemical structure of the compound, researchers may be able to create analogs with enhanced therapeutic effects or decreased toxicity. This could lead to the development of novel drugs with improved pharmacological profiles for a range of medical conditions.
🧪 Related Compounds
One similar compound to 2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid is 2-Amino-3-(4-hydroxyphenyl)propanoic acid. This compound has a similar molecular structure to the original compound, with the only difference being the absence of iodine atoms on the phenyl ring. The substitution of diiodophenyl with phenyl alters the chemical properties of the compound.
Another similar compound is 2-Amino-3-(4-hydroxy-3-iodophenyl)propanoic acid. This compound retains the iodine atom on the phenyl ring, similar to the original compound, but lacks the second iodine atom. The structural difference between this compound and 2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid lies in the number of iodine atoms attached to the phenyl ring.
A third similar compound is 2-Amino-3-(4-hydroxy-5-iodophenyl)propanoic acid. This compound shares a similar structure with the original compound, with the main distinction being the position of the iodine atoms on the phenyl ring. The rearrangement of iodine atoms within the phenyl ring alters the chemical properties and potential biological activities of this compound compared to 2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid.
