1H-Indol-3-ol, also known as indole-3-carbinol, is a compound found in cruciferous vegetables such as broccoli, cabbage, and Brussels sprouts. This compound has been the subject of numerous studies due to its potential health benefits, particularly in relation to cancer prevention.
Research has shown that 1H-Indol-3-ol may help to inhibit the development of certain types of cancer by suppressing the growth of cancer cells and promoting their destruction. Additionally, this compound has been linked to the regulation of estrogen metabolism, which may have implications for hormone-related conditions such as breast cancer.
In everyday life, incorporating cruciferous vegetables into one’s diet can provide a natural source of 1H-Indol-3-ol, potentially contributing to improved health and a reduced risk of certain cancers. While further research is needed to fully understand the effects of this compound, its relevance to everyday life lies in the potential health benefits associated with consuming foods rich in indole-3-carbinol.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
1H-Indol-3-ol, commonly known as tryptophol, has several commercial and industrial applications. It is used in the production of fragrances due to its pleasant odor, making it a popular ingredient in perfumes, soaps, and lotions. Additionally, tryptophol is utilized in the manufacturing of pharmaceuticals and agrochemicals, serving as a precursor in the synthesis of several important compounds.
In terms of drug and medication applications, 1H-Indol-3-ol plays a crucial role in the pharmaceutical industry. It is a precursor in the synthesis of serotonin, a neurotransmitter that regulates mood, appetite, and sleep. Serotonin is also involved in the treatment of various neurological disorders such as depression, anxiety, and migraines. Furthermore, tryptophol is used in the preparation of sedative and hypnotic drugs, contributing to its significance in the field of medicine.
Overall, 1H-Indol-3-ol exhibits diverse commercial and industrial applications, ranging from fragrance production to pharmaceutical synthesis. Its role as a precursor in the creation of serotonin and other important compounds highlights its significance in the development of medications for various neurological disorders. The versatile nature of tryptophol makes it a valuable asset in both the commercial and medicinal sectors.
⚗️ Chemical & Physical Properties
1H-Indol-3-ol appears as a white crystalline solid with a mild, characteristic odor. It is commonly used in the production of pharmaceuticals and fragrances due to its unique aroma.
The molar mass of 1H-Indol-3-ol is approximately 131.15 g/mol, and its density is around 1.23 g/cm³. When compared to common food items like sugar (molar mass 342.3 g/mol, density 1.59 g/cm³), 1H-Indol-3-ol has a lower molar mass and density.
1H-Indol-3-ol has a melting point of around 122-124°C and a boiling point of approximately 256-257°C. When compared to common food items like butter (melting point 32-35°C, boiling point 150°C), 1H-Indol-3-ol has a higher melting point and boiling point.
1H-Indol-3-ol is sparingly soluble in water and has a relatively low viscosity. Compared to common food items like salt (high solubility in water, low viscosity) and honey (soluble in water, high viscosity), 1H-Indol-3-ol exhibits different solubility and viscosity properties.
🏭 Production & Procurement
1H-Indol-3-ol, also known as indoxyl alcohol, is typically produced through the chemical synthesis of indole and hydrogen peroxide. This reaction yields the desired compound, which can then be further purified and isolated using various chromatographic techniques. The high purity of 1H-Indol-3-ol is crucial for its use in pharmaceutical and research applications.
The procurement of 1H-Indol-3-ol involves sourcing the necessary starting materials, such as indole and hydrogen peroxide, from reputable chemical suppliers. These compounds are typically purchased in bulk quantities to ensure a steady supply for production purposes. Once obtained, the synthesis of 1H-Indol-3-ol can be carried out in a laboratory setting under controlled conditions to maximize yield and purity.
After production, 1H-Indol-3-ol can be transported in various forms, including solid crystals or dissolved in a suitable solvent for ease of handling. Care must be taken to ensure the safe transport of the compound, as it may be sensitive to light, heat, or moisture. Proper labeling and documentation are essential to comply with regulations regarding the shipment of chemicals, especially those intended for pharmaceutical or research use.
⚠️ Safety Considerations
Safety considerations for 1H-Indol-3-ol should be taken seriously due to its potential hazards. When handling this compound, it is important to wear appropriate personal protective equipment such as gloves, goggles, and lab coat to prevent any skin contact or inhalation of vapors. In case of accidental exposure, it is crucial to immediately wash the affected area with plenty of water and seek medical attention if necessary. Additionally, proper ventilation should be ensured when working with 1H-Indol-3-ol to avoid inhalation of potentially harmful fumes.
The hazard statements for 1H-Indol-3-ol include “Causes skin irritation,” “Causes serious eye irritation,” and “May cause respiratory irritation.” These statements highlight the potential risks associated with this compound and emphasize the importance of taking necessary precautions to minimize exposure. It is crucial to handle 1H-Indol-3-ol with care and follow safety guidelines to prevent any adverse effects on health.
Precautionary statements for 1H-Indol-3-ol include “Wear protective gloves/eye protection/face protection,” “IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing,” and “Get medical advice/attention if you feel unwell.” These statements provide guidance on how to safely handle 1H-Indol-3-ol and what to do in case of accidental exposure. By following these precautions, individuals can reduce the risks associated with working with this compound and ensure their safety in the laboratory setting.
🔬 Potential Research Directions
One potential research direction for 1H-Indol-3-ol is exploring its role as a building block for the synthesis of various bioactive compounds. Researchers may investigate the pharmacological properties and the potential therapeutic applications of derivatives derived from 1H-Indol-3-ol.
Another avenue for research could involve investigating the chemical reactivity and mechanisms of reactions involving 1H-Indol-3-ol. Understanding the reactivity of this compound could lead to the development of new synthetic methodologies or the discovery of novel transformations that could be applied in organic synthesis.
Furthermore, researchers may focus on studying the biological activities of 1H-Indol-3-ol and its derivatives. This could involve exploring their effects on biological pathways, such as their potential as anti-inflammatory agents, anticancer agents, or their role in modulating neurotransmitter systems. Such studies could provide valuable insights into the biological significance of this compound.
🧪 Related Compounds
One similar compound to 1H-Indol-3-ol based on molecular structure is 1H-Indole-3-acetic acid. This compound is also known as indole-3-acetic acid (IAA) and is a plant hormone that plays a crucial role in regulating plant growth and development. It is structurally similar to 1H-Indol-3-ol, with an additional carboxylic acid group attached to the indole ring. Indole-3-acetic acid is widely studied for its effects on plant physiology and is commonly used in agriculture to promote root growth and fruit development.
Another compound similar to 1H-Indol-3-ol is 1H-Indole-3-carbinol, also known as indole-3-carbinol (I3C). This compound is derived from the breakdown of glucobrassicin, a compound found in cruciferous vegetables like broccoli and cabbage. Indole-3-carbinol is structurally related to 1H-Indol-3-ol, with an additional methyl group attached to the carbon adjacent to the indole ring. Indole-3-carbinol is of interest for its potential anti-cancer properties and is being studied for its role in hormone regulation and detoxification processes in the body.
One more compound similar to 1H-Indol-3-ol is 1H-Indole-3-propionic acid. This compound, also known as indole-3-propionic acid (IPA), is a tryptophan metabolite formed by gut bacteria in the human digestive system. Structurally similar to 1H-Indol-3-ol, indole-3-propionic acid features a propionic acid group attached to the indole ring. Indole-3-propionic acid has been implicated in various physiological processes, including anti-inflammatory and neuroprotective effects, making it a topic of interest in research on gut-brain axis communication and overall health.
