17-Ethynylestra-1(10),2,4-triene-3,17-diol, commonly known as Ethinyl Estradiol, is a synthetic form of the hormone estrogen. This compound is widely used in oral contraceptives and hormone replacement therapy, making it a crucial component in women’s healthcare. By regulating hormone levels, Ethinyl Estradiol helps prevent pregnancy and manage symptoms of menopause. Its significance in everyday life lies in its ability to empower women to make informed choices about their reproductive health and overall well-being.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
17-Ethynylestra-1(10),2,4-triene-3,17-diol, also known as Ethynylestradiol, is a synthetic estrogen used in various commercial and industrial applications. It is commonly utilized in hormonal contraception products, such as combined oral contraceptive pills and contraceptive patches. Ethynylestradiol is also employed in hormone replacement therapy for menopausal women, as well as in the treatment of certain gynecological conditions.
In addition to its commercial and industrial applications, Ethynylestradiol plays a crucial role in the field of drug development and medication. It is a key component in various prescription medications, particularly those used in the treatment of endometriosis, dysmenorrhea, and certain types of cancers such as prostate cancer and breast cancer. Ethynylestradiol is also utilized in hormone therapy for transgender individuals undergoing gender transition.
The versatility of Ethynylestradiol extends beyond its conventional applications, as it is also utilized in scientific research and laboratory experiments. Its estrogenic properties make it a valuable tool in the study of hormonal regulation and reproductive biology. Moreover, Ethynylestradiol is employed in the development of novel drug delivery systems and formulations, aimed at enhancing the efficacy and safety of hormonal therapies.
⚗️ Chemical & Physical Properties
17-Ethynylestra-1(10),2,4-triene-3,17-diol appears as a white, crystalline solid with no distinctive odor. It is a synthetic hormone commonly used in oral contraceptives and hormone replacement therapy.
The molar mass of 17-Ethynylestra-1(10),2,4-triene-3,17-diol is approximately 296.41 g/mol, and its density is around 1.39 g/cm³. In comparison to common food items, such as sugar (molar mass of 342.3 g/mol and density of 1.59 g/cm³), it has a lower molar mass and slightly lower density.
The melting point of 17-Ethynylestra-1(10),2,4-triene-3,17-diol is approximately 180-182°C, and its boiling point is around 674-676°C. Compared to common food items like butter (melting point of around 32-35°C and boiling point of around 150-200°C), it has much higher melting and boiling points.
17-Ethynylestra-1(10),2,4-triene-3,17-diol is practically insoluble in water but soluble in organic solvents. It has a low viscosity, making it easy to handle in laboratory settings. Compared to common food items like salt (soluble in water) and honey (viscous), it demonstrates different solubility and viscosity properties.
🏭 Production & Procurement
In the production of 17-Ethynylestra-1(10),2,4-triene-3,17-diol, a key starting material is typically ethynyl estradiol, which undergoes a series of chemical transformations to yield the desired compound. This may involve multiple steps of synthesis, purification, and isolation to ensure high purity and yield of the final product. Careful control of reaction conditions and precise manipulation of reagents are essential in the production process.
17-Ethynylestra-1(10),2,4-triene-3,17-diol can be procured from specialized chemical suppliers that produce and sell a wide range of organic compounds for research and industrial purposes. The compound is usually available in varying quantities, from small-scale research quantities to bulk quantities for industrial applications. Proper handling and transport of 17-Ethynylestra-1(10),2,4-triene-3,17-diol are crucial to ensure product integrity and safety, with adherence to regulations governing the transportation of hazardous chemicals.
For transport, 17-Ethynylestra-1(10),2,4-triene-3,17-diol is typically packaged and labeled according to international regulations on the transportation of dangerous goods. It may be shipped in sealed containers that prevent leakage and contamination during transit. Specialized carriers with expertise in handling hazardous chemicals are often employed to ensure the safe and secure delivery of 17-Ethynylestra-1(10),2,4-triene-3,17-diol to its intended destination.
⚠️ Safety Considerations
Safety considerations for handling 17-Ethynylestra-1(10),2,4-triene-3,17-diol include the need for personal protective equipment such as gloves, goggles, and lab coats to prevent direct skin contact and inhalation of the compound. It is important to work in a well-ventilated area to minimize exposure to vapors or fumes. Proper storage of the chemical in a cool, dry place away from incompatible substances is essential to prevent accidental reactions or spills. In case of accidental exposure, immediate medical attention should be sought, and the appropriate first aid measures should be administered.
The hazard statements for 17-Ethynylestra-1(10),2,4-triene-3,17-diol include “Causes severe skin burns and eye damage” and “May cause respiratory irritation.” These statements indicate that the compound has the potential to cause harm upon contact with skin, eyes, or respiratory system. It is important to handle this chemical with caution to prevent any adverse effects on health.
Precautionary statements for handling 17-Ethynylestra-1(10),2,4-triene-3,17-diol include “Wear protective gloves/protective clothing/eye protection/face protection” and “IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing.” These statements emphasize the importance of wearing appropriate protective gear and taking immediate action in case of contact with the compound. It is crucial to follow these precautions to minimize the risk of exposure and ensure safe handling of the chemical.
🔬 Potential Research Directions
Research on 17-Ethynylestra-1(10),2,4-triene-3,17-diol could explore its potential as a novel contraceptive agent, given its structural similarity to other hormonal contraceptives. Investigations into its efficacy in preventing pregnancy and potential side effects would be of interest to the scientific community.
Further studies could focus on the pharmacokinetics and metabolism of 17-Ethynylestra-1(10),2,4-triene-3,17-diol in the human body, to better understand its mechanism of action and potential interactions with other drugs. This could inform dosing regimens and improve the safety profile of this compound.
Exploration of the impact of 17-Ethynylestra-1(10),2,4-triene-3,17-diol on endocrine function and its potential role in hormone replacement therapy could also be a fruitful avenue of research. Understanding its effects on hormonal balance and reproductive health could have significant implications for women’s health.
🧪 Related Compounds
One similar compound to 17-Ethynylestra-1(10),2,4-triene-3,17-diol is Ethinylestradiol. This compound contains a similar ethynyl group at the 17 position, but lacks the hydroxyl group at position 3. Ethinylestradiol is commonly used in oral contraceptives due to its potent estrogenic activity.
Another compound with a similar structure is Norethindrone. This compound also contains an ethynyl group at the 17 position, but has a ketone group at position 3 instead of a hydroxyl group. Norethindrone is a progestin used in hormonal contraceptives and hormone replacement therapy for menopausal symptoms.
A further compound with a resemblance to 17-Ethynylestra-1(10),2,4-triene-3,17-diol is Levonorgestrel. This compound is a progestin with a slightly different structure, containing a methyl group at position 13. Levonorgestrel is commonly used in emergency contraception and hormonal intrauterine devices.
