17-Deoxyestradiol is a naturally occurring hormone that plays a crucial role in the regulation of various bodily functions, particularly in the female reproductive system. It is also being studied for its potential therapeutic applications in treating hormone-responsive cancers and other conditions. Understanding the functions and potential benefits of 17-Deoxyestradiol can provide valuable insights into the complexities of human physiology and may offer new avenues for medical research and treatment options in everyday life.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
Commercial and industrial applications of 17-Deoxyestradiol are limited due to its potential side effects and toxicity. However, it has been studied for its potential use in cancer research and as a precursor for the synthesis of other compounds.
In terms of drug and medication applications, 17-Deoxyestradiol has shown promise in the treatment of hormone-sensitive cancers, such as breast and prostate cancer. It works by inhibiting the growth of cancer cells and interfering with hormone receptors.
Studies have also explored the potential use of 17-Deoxyestradiol in hormone replacement therapy for menopausal women or those with estrogen deficiencies. However, further research is needed to fully understand its efficacy and safety in these applications.
⚗️ Chemical & Physical Properties
17-Deoxyestradiol is a white crystalline powder with no distinctive odor. It is virtually odorless and appears as fine particles.
The molar mass of 17-Deoxyestradiol is approximately 288.41 g/mol, and its density is around 1.25 g/cm3. In comparison to common food items like sugar (180.16 g/mol, 1.59 g/cm3) and salt (58.44 g/mol, 2.16 g/cm3), 17-Deoxyestradiol has a higher molar mass but lower density.
The melting point of 17-Deoxyestradiol is approximately 163-167°C, while its boiling point is around 400-450°C. In contrast, common food items like butter (32-35°C melting point, 150-175°C boiling point) and chocolate (32-34°C melting point, 160-170°C boiling point) have lower melting and boiling points.
17-Deoxyestradiol is sparingly soluble in water and exhibits low viscosity. This contrasts with common food items like sugar and salt, which are highly soluble in water and have higher viscosity levels.
🏭 Production & Procurement
17-Deoxyestradiol is a compound that can be produced synthetically through chemical processes. One method involves starting with estrone, a naturally occurring estrogen, and removing the hydroxyl group at position 17 to create 17-Deoxyestradiol. Another approach is to start with 17β-hydroxyandrost-4-en-3-one and carry out a series of chemical reactions to obtain the desired compound.
17-Deoxyestradiol can be procured through commercial suppliers that specialize in providing research chemicals and pharmaceutical intermediates. These suppliers typically offer 17-Deoxyestradiol in various forms, such as powder or solution, and in different purities to meet the needs of researchers and pharmaceutical companies. The compound can be transported in sealed containers to prevent contamination and degradation during transit.
When procuring 17-Deoxyestradiol, it is important to consider the storage and handling requirements of the compound. It should be stored in a cool, dry place away from light and heat sources to maintain its stability. Proper labeling and documentation of the compound are essential for tracking and inventory management. Additionally, precautions should be taken during transportation to ensure the safe delivery of 17-Deoxyestradiol to its intended destination.
⚠️ Safety Considerations
Safety considerations for 17-Deoxyestradiol include potential hazards associated with its use. It is important to handle this compound with caution as it may cause skin irritation, eye irritation, and respiratory irritation. Proper protective equipment, such as gloves, goggles, and a mask, should be worn when working with 17-Deoxyestradiol to minimize exposure and reduce the risk of adverse effects.
Furthermore, it is essential to store 17-Deoxyestradiol in a secure location away from incompatible substances to prevent accidents or spills. This compound should be kept in a well-ventilated area and stored in its original container to maintain its integrity and prevent contamination. Proper labeling of containers is also crucial to ensure that the compound is correctly identified and handled in accordance with safety guidelines.
In summary, hazard statements for 17-Deoxyestradiol include the potential for skin, eye, and respiratory irritation upon exposure. It is important to handle this compound with caution and adhere to safety protocols to minimize the risk of adverse effects. Protective equipment should be worn, and proper storage and labeling procedures should be followed to ensure safe handling and containment of 17-Deoxyestradiol.
Precautionary statements for 17-Deoxyestradiol include recommendations for safe handling and storage to minimize the risk of exposure and adverse effects. It is important to avoid inhaling, ingesting, or contacting this compound with skin or eyes to prevent irritation or other health hazards. Proper ventilation, protective equipment, and proper labeling of containers are essential for safe handling and storage of 17-Deoxyestradiol.
Additionally, it is crucial to wash hands thoroughly after handling 17-Deoxyestradiol and to seek medical attention in case of accidental exposure or ingestion. Personnel working with this compound should be trained in safe handling practices and emergency procedures to respond effectively in case of spills or accidents. By following precautionary measures and safety guidelines, the risk of adverse effects associated with 17-Deoxyestradiol can be minimized, ensuring a safe working environment.
🔬 Potential Research Directions
Research on 17-Deoxyestradiol, a derivative of estradiol, shows promise in the field of cancer therapy due to its antiangiogenic properties.
Current studies suggest that 17-Deoxyestradiol may have potential applications in treating hormone-related cancers, such as breast and prostate cancer, by inhibiting the growth of blood vessels that feed tumors.
Further investigation is needed to explore the exact mechanisms through which 17-Deoxyestradiol functions as an antiangiogenic agent, as well as its potential side effects and interactions with other cancer treatments.
🧪 Related Compounds
One similar compound to 17-Deoxyestradiol based upon molecular structure is Estriol. Estriol is a naturally occurring estrogen that is derived from estradiol and is characterized by a hydroxyl group at the C3 position. This compound is primarily produced during pregnancy and has weaker estrogenic activity compared to estradiol.
Another compound with a similar structure to 17-Deoxyestradiol is Estrone. Estrone is an estrogen hormone that is produced in the body through the conversion of androstenedione. It has a keto group at the C3 position, distinguishing it from estradiol and estriol. Estrone is weaker than estradiol in terms of estrogenic potency but plays a key role as a precursor to both estradiol and estriol.
A further compound that shares a resemblance to 17-Deoxyestradiol in terms of molecular structure is Ethinylestradiol. Ethinylestradiol is a synthetic estrogen used in combination with progestins in many hormonal contraceptives. It contains an ethinyl group at the C17 position, making it resistant to metabolism by liver enzymes. Despite being more potent than natural estrogens like estradiol, ethinylestradiol has an increased risk of adverse effects due to its chemical modifications.
