1,3,5-Trifluorobenzene 

1,3,5-Trifluorobenzene is a chemical compound with several practical applications in everyday life. It is commonly used as an intermediate in the production of pharmaceuticals, agrochemicals, and electronic materials. Additionally, it serves as a precursor in the synthesis of various organic compounds, making it an important building block in the chemical industry. The versatility of 1,3,5-Trifluorobenzene contributes to its relevance in a wide range of consumer products and industrial processes.

Table of Contents:

• 💡  Commercial Applications
• ⚗️  Chemical & Physical Properties
• 🏭  Production & Procurement
• ⚠️  Safety Considerations
• 🔬  Potential Research Directions
• 🧪  Related Compounds

💡  Commercial Applications

1,3,5-Trifluorobenzene, a colorless liquid with a strong odor, has been utilized in various commercial and industrial applications. It is commonly used as a solvent in chemical reactions and as an intermediate in the synthesis of pharmaceuticals and agrochemicals. In addition, it is employed in the production of specialty polymers, electronics, and coatings due to its unique chemical properties.

In terms of drug and medication applications, 1,3,5-Trifluorobenzene has been explored for its potential use in developing new pharmaceutical compounds. Researchers have investigated its role as a building block for drug molecules with enhanced biological activity and reduced toxicity. Its ability to modify the structure of organic molecules has shown promise in the discovery of novel drug candidates for various therapeutic purposes.

⚗️  Chemical & Physical Properties

1,3,5-Trifluorobenzene is a colorless liquid with a faint aromatic odor. Its appearance is that of a clear substance with a mild scent, making it easily distinguishable in a laboratory setting.

The molar mass of 1,3,5-Trifluorobenzene is 146.05 g/mol, and its density is approximately 1.387 g/mL. When compared to common food items, such as sugar (molar mass of 342.30 g/mol) and water (density of 1 g/mL), 1,3,5-Trifluorobenzene has a lower molar mass and a higher density.

1,3,5-Trifluorobenzene has a melting point of -37.3°C and a boiling point of 130.5°C. In comparison, common food items like butter (melting point of 32-35°C) and water (boiling point of 100°C) have higher melting and boiling points, respectively, than 1,3,5-Trifluorobenzene.

1,3,5-Trifluorobenzene is insoluble in water but soluble in organic solvents, and it exhibits a low viscosity. When compared to common food items like salt (high solubility in water) and honey (high viscosity), 1,3,5-Trifluorobenzene shows contrasting properties with low solubility in water and low viscosity.

🏭  Production & Procurement

1,3,5-Trifluorobenzene is typically produced through the nitration of benzene with a mixture of nitric and sulfuric acid. The nitrobenzene is then fluorinated using elemental fluorine or a fluorinating agent to yield 1,3,5-Trifluorobenzene. This process requires strict adherence to safety protocols due to the reactivity of the chemicals involved.

1,3,5-Trifluorobenzene can be procured from chemical suppliers that specialize in fluorinated compounds. It is commonly available in varying purities, from technical grade to high purity suitable for research applications. The compound is typically transported in sealed containers to prevent contamination or degradation during transit.

Due to the hazardous nature of 1,3,5-Trifluorobenzene, proper precautions must be taken during its procurement and transportation. Handlers should be trained in safe handling procedures and wear appropriate personal protective equipment. Additionally, the compound should be stored in a cool, dry place away from sources of heat or ignition to prevent accidents.

⚠️  Safety Considerations

Safety considerations for 1,3,5-Trifluorobenzene should be taken seriously due to its potential hazards. When handling this compound, it is important to wear appropriate personal protective equipment, such as gloves, goggles, and a lab coat, to prevent skin contact, eye irritation, and inhalation of vapors. It is recommended to work with 1,3,5-Trifluorobenzene in a well-ventilated area to minimize exposure and reduce the risk of respiratory issues.

In the event of a spill or accidental release of 1,3,5-Trifluorobenzene, prompt action should be taken to contain the substance and prevent further contamination. It is important to have appropriate spill response procedures in place and to have spill containment materials readily available. Additionally, it is crucial to follow proper waste disposal protocols for 1,3,5-Trifluorobenzene to ensure environmental safety and compliance with regulations.

Hazard statements for 1,3,5-Trifluorobenzene include “Causes skin irritation” and “Causes serious eye irritation.” These statements indicate the potential for skin and eye irritation upon contact with the substance. It is important to take precautions to avoid skin and eye exposure when working with 1,3,5-Trifluorobenzene, such as wearing protective gloves and goggles. Furthermore, it is essential to seek medical attention if skin or eye irritation occurs and to wash off any exposed skin or eyes with plenty of water.

Precautionary statements for 1,3,5-Trifluorobenzene include “Wear protective gloves/protective clothing/eye protection/face protection” and “IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing.” These statements emphasize the importance of wearing appropriate personal protective equipment and taking immediate action in the event of skin exposure to 1,3,5-Trifluorobenzene. It is crucial to follow these precautionary measures to minimize the risk of adverse health effects and ensure safe handling of the compound.

🔬  Potential Research Directions

One potential research direction for 1,3,5-Trifluorobenzene involves its use as a building block in organic synthesis. By utilizing its unique fluorine substituents, new compounds with potential pharmaceutical or material applications can be synthesized.

Another area of interest could be in studying the reactivity of 1,3,5-Trifluorobenzene with different reagents to explore the formation of novel functionalized derivatives. This research could provide valuable insights into the chemical behavior of this compound and its potential utility in various industries.

Furthermore, investigating the electronic properties of 1,3,5-Trifluorobenzene through computational chemistry methods could shed light on its potential as a semiconductor or in other electronic applications. Understanding its electronic structure could lead to the design of new materials with tailored properties for specific technological needs.

🧪  Related Compounds

One similar compound to 1,3,5-Trifluorobenzene is 1,2,4-Trifluorobenzene. This compound has a similar molecular structure, with three fluorine atoms attached to a benzene ring in positions 1, 2, and 4. This compound exhibits similar chemical properties to 1,3,5-Trifluorobenzene due to the arrangement of the fluorine atoms on the benzene ring.

Another related compound is 1,2,3-Trifluorobenzene. This compound also features three fluorine atoms attached to a benzene ring, but in positions 1, 2, and 3 instead of 1, 3, and 5 as in 1,3,5-Trifluorobenzene. Despite the difference in the position of the fluorine atoms, 1,2,3-Trifluorobenzene shares similar chemical properties with 1,3,5-Trifluorobenzene due to the presence of three fluorine substituents on the benzene ring.

Additionally, 1,2,4,5-Tetrafluorobenzene is another compound with a molecular structure similar to 1,3,5-Trifluorobenzene. This compound has four fluorine atoms attached to a benzene ring in positions 1, 2, 4, and 5, resulting in a closely related chemical structure to 1,3,5-Trifluorobenzene. Despite the additional fluorine substituent, 1,2,4,5-Tetrafluorobenzene may exhibit similar chemical reactivity and properties to 1,3,5-Trifluorobenzene due to the common benzene ring backbone and fluorine substituents.