10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate

10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate, commonly known as paclitaxel, is a chemotherapy medication used in the treatment of various types of cancer, including breast, lung, and ovarian cancers. Its relevance to everyday life lies in its ability to combat and potentially cure life-threatening diseases, offering hope to millions of patients worldwide. The development and administration of paclitaxel represent a crucial advancement in medical science, providing individuals with a fighting chance against serious illnesses, thereby greatly impacting the quality and longevity of their lives.

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💡  Commercial Applications

10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate, often referred to as a synthetic derivative of the natural product taxol, has several commercial and industrial applications. One of the primary uses of this compound is in the production of anticancer drugs due to its potent antitumor activity. Additionally, it is commonly utilized in the pharmaceutical industry for the development of novel drug formulations and treatments.

In the realm of drug and medication applications, 10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate plays a crucial role in the treatment of various types of cancer. It is frequently incorporated into chemotherapy regimens for patients diagnosed with breast, ovarian, and lung cancer, among others. The compound’s ability to inhibit microtubule formation in cancer cells makes it a valuable component in targeted cancer therapies.

Furthermore, 10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate has shown promise in the field of drug delivery systems. Its ability to enhance the bioavailability and efficacy of other therapeutic agents makes it a key ingredient in the development of innovative drug delivery platforms. This has opened up new avenues for improving the pharmacokinetics and therapeutic outcomes of various medications, ultimately benefiting patients worldwide.

⚗️  Chemical & Physical Properties

10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate appears as a colorless solid with a distinct odor. The compound is crystalline in nature, with a subtle scent resembling that of pine trees.

With a molar mass of approximately 426.66 g/mol, 10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate is considerably heavier than most common food items. Its density is around 1.2 g/cm3, which is higher than the densities of many food products.

The melting point of 10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate is approximately 178-180°C, while its boiling point is around 380-400°C. These values are significantly higher than those of most common food items, making the compound more stable at high temperatures.

10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate is sparingly soluble in water, but it exhibits moderate viscosity. Compared to common food items, its solubility in water is lower, and its viscosity is higher, giving it distinct physical properties in aqueous solutions.

🏭  Production & Procurement

10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate is produced through a complex chemical synthesis process involving various reagents and reaction conditions. This compound is a semi-synthetic derivative of taxol, a potent anticancer agent derived from the Pacific yew tree. The production of 10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate requires high levels of expertise in organic chemistry.

10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate can be procured from specialized chemical suppliers that produce and sell research chemicals. This compound is often transported in sealed containers to prevent degradation or contamination during transit. Due to its sensitive nature, 10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate must be handled with care and stored under specific conditions to maintain its stability.

Researchers and pharmaceutical companies may procure 10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate for experimental purposes or drug development efforts. The procurement of this compound typically involves placing orders with chemical suppliers and coordinating shipment details. It is essential to follow proper safety protocols when handling and transporting 10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate to ensure the integrity of the compound and the safety of individuals involved in its handling.

⚠️  Safety Considerations

Safety considerations for 10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate include the need for proper storage in a cool, dry, well-ventilated area away from sources of heat or ignition. When handling this compound, it is essential to wear appropriate personal protective equipment such as gloves, safety goggles, and a lab coat to prevent skin contact or inhalation of fumes. In case of accidental exposure, thorough washing of affected areas with soap and water is recommended, and medical attention should be sought if symptoms persist.

Regarding hazard statements for 10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate, it is important to note that this compound may be harmful if swallowed, inhaled, or comes into contact with skin. Exposure to this substance may cause irritation to the respiratory system, skin, and eyes. Prolonged or repeated exposure may result in more severe health effects, including dermatitis or respiratory distress.

Precautionary statements for 10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate include avoiding direct contact with the substance and ensuring proper ventilation when working with it. It is advisable to use this compound in a designated area with appropriate engineering controls to minimize exposure. Additionally, hands should be washed thoroughly after handling, and contaminated clothing should be removed immediately. In case of spills, proper cleanup procedures and disposal methods should be followed to prevent environmental contamination.

🔬  Potential Research Directions

One potential research direction for 10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate is investigating its anti-cancer properties, particularly in its ability to inhibit cell growth and induce apoptosis in cancer cells.

Another avenue of study could focus on exploring the potential mechanisms of action of this compound, such as its interactions with specific proteins or signaling pathways within cells.

Additionally, researchers may be interested in investigating the potential use of 10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate as a novel therapeutic agent for the treatment of other diseases, such as inflammatory disorders or neurodegenerative conditions.

Further research could also involve studying the pharmacokinetics and pharmacodynamics of this compound, including its absorption, distribution, metabolism, and excretion in the body, as well as its biological effects and toxicity profile.

One similar compound to 10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate based on its molecular structure is 10beta-Acetoxytaxa-4(20),11-dien-5alpha-ol. This compound differs from the original structure by having an acetoxy group instead of a hydroxy group at the 10th position, and an alcohol group at the 5th position instead of an acetyl group.

Another compound with a similar structure is 10beta-Methoxytaxa-4(20),11-dien-5alpha-yl acetate. In this compound, the hydroxy group at the 10th position is replaced by a methoxy group, while the acetate group at the 5th position is retained. This alteration in functional groups results in a compound with distinct chemical properties.

10beta-Hydroxytaxa-4(20),11-dien-5alpha-yl acetate can also be compared to 10beta, 20-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate. In this compound, there are hydroxy groups at both the 10th and 20th positions instead of just one hydroxy group at the 10th position. This difference in substitution pattern leads to variations in the compound’s biological activity and potential applications.

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