1-Methyl-2-piperidone, a chemical compound commonly used in pharmaceuticals, agrochemicals, and other industrial applications, plays a significant role in everyday life. This compound is utilized in the production of medications, agricultural chemicals, and various manufacturing processes. Its properties make it a valuable ingredient in the pharmaceutical industry, where it is utilized in the synthesis of various drugs. Additionally, 1-Methyl-2-piperidone is an essential component in the production of pesticides and herbicides, contributing to the maintenance of agricultural productivity. Overall, the widespread use of this compound highlights its importance in various facets of daily life and industry.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
1-Methyl-2-piperidone, also known as NMP, is commonly used in a variety of commercial and industrial applications. It is widely utilized as a solvent in the production of specialty chemicals, pharmaceuticals, and polymers. Additionally, it is an effective stripper in the electronics industry for removing photoresists and solder masks.
In the realm of drug and medication applications, 1-Methyl-2-piperidone plays a significant role as a pharmaceutical intermediate. It is often used in the synthesis of various medications, including analgesics, antipsychotics, and antidepressants. Due to its versatile nature and high reactivity, it is a valuable component in the pharmaceutical industry for the development of new drug compounds.
Overall, the commercial and industrial applications of 1-Methyl-2-piperidone are diverse and essential in various fields. From serving as a solvent in chemical manufacturing to playing a crucial role in drug synthesis, its versatility makes it a valuable compound for numerous applications. As technology continues to advance, the demand for 1-Methyl-2-piperidone is expected to grow, further solidifying its importance in the commercial and industrial sectors.
⚗️ Chemical & Physical Properties
1-Methyl-2-piperidone appears as a colorless liquid with a faint amine-like odor. It is commonly used as a chemical intermediate in the production of various pharmaceuticals and agrochemicals.
With a molar mass of 99.13 g/mol and a density of 1.02 g/cm^3, 1-Methyl-2-piperidone is heavier than common food items such as water and sugar. Its molar mass is comparable to that of glucose, while its density is similar to that of vegetable oil.
1-Methyl-2-piperidone has a melting point of -30°C and a boiling point of 156°C. These values are significantly higher compared to common food items such as water and ethanol. Water, for example, has a melting point of 0°C and a boiling point of 100°C.
The compound is soluble in water and exhibits low viscosity. This makes it easier to handle and mix in solution compared to common food items like sugar, which may have limited solubility and high viscosity in water.
🏭 Production & Procurement
1-Methyl-2-piperidone is commonly produced through the reaction of 1-methyl-2-pyrrolidinone with formaldehyde and hydrogen gas over a catalyst, typically palladium on carbon. This process, known as the Leuckart-Wallach reaction, yields high purity 1-Methyl-2-piperidone suitable for industrial applications.
1-Methyl-2-piperidone can be procured from specialized chemical suppliers that cater to industrial users. The compound is typically sold in bulk quantities and is often transported in drums or intermediate bulk containers (IBCs) to customers. Due to its potential reactivity and toxicity, proper handling procedures must be followed during transportation to ensure safety.
Alternatively, 1-Methyl-2-piperidone can be synthesized in-house by chemical manufacturers for specific applications. This approach allows for greater control over the production process and can result in cost savings for companies with high demand for the compound. However, strict quality control measures must be in place to ensure the purity and consistency of the final product.
⚠️ Safety Considerations
Safety Considerations for 1-Methyl-2-piperidone:
When handling 1-Methyl-2-piperidone, it is important to wear appropriate personal protective equipment, including gloves, goggles, and a lab coat, to prevent skin contact and inhalation of the chemical. Adequate ventilation should be ensured in the work area to minimize exposure to vapors. In case of accidental exposure, immediate medical attention should be sought, and the Material Safety Data Sheet for 1-Methyl-2-piperidone should be consulted for guidance on appropriate first aid measures.
Hazard Statements for 1-Methyl-2-piperidone:
1-Methyl-2-piperidone is classified as a hazardous chemical due to its potential health effects. Hazard statements for 1-Methyl-2-piperidone include “Causes skin irritation,” “Causes serious eye irritation,” and “May cause respiratory irritation.” It is important to handle this chemical with care and follow proper safety protocols to minimize the risk of exposure and potential health hazards.
Precautionary Statements for 1-Methyl-2-piperidone:
To ensure safe handling of 1-Methyl-2-piperidone, precautionary statements should be followed. These include “Wash hands thoroughly after handling,” “Wear protective gloves/eye protection/face protection,” and “Use only outdoors or in a well-ventilated area.” By following these precautionary statements, the risk of exposure to 1-Methyl-2-piperidone can be minimized, and a safe working environment can be maintained.
🔬 Potential Research Directions
1-Methyl-2-piperidone, a versatile chemical compound, presents numerous opportunities for research in various fields. One potential research direction involves investigating its applications in organic synthesis as a solvent or reagent, due to its unique structure and properties.
Furthermore, studies could be carried out to explore the potential pharmaceutical applications of 1-Methyl-2-piperidone. This could include investigating its potential as a drug intermediate or as an active pharmaceutical ingredient in the development of new medications.
In addition, researchers may find it valuable to study the toxicological properties of 1-Methyl-2-piperidone, in order to assess its safety for various applications. This could involve evaluating its potential for skin irritation, inhalation hazards, or other adverse effects.
Overall, the diverse potential research directions for 1-Methyl-2-piperidone highlight its importance as a compound with various possible applications in chemistry, pharmacology, and other scientific fields. Further investigation into its properties and potential uses could yield valuable insights and applications.
🧪 Related Compounds
One similar compound to 1-Methyl-2-piperidone is N-methyl-2-pyrrolidinone. This compound also contains a five-membered ring with nitrogen and a methyl group attached to the nitrogen atom. N-methyl-2-pyrrolidinone is commonly used as a solvent in various chemical reactions and has similar physical and chemical properties to 1-Methyl-2-piperidone.
Another compound with a similar molecular structure to 1-Methyl-2-piperidone is N-ethyl-2-piperidone. In this compound, there is an ethyl group attached to the nitrogen atom in the five-membered piperidine ring. N-ethyl-2-piperidone is used in the synthesis of various pharmaceuticals and agrochemicals due to its similar reactivity and properties to 1-Methyl-2-piperidone.
Additionally, N-methyl-2-morpholinone is a compound that shares a common structural motif with 1-Methyl-2-piperidone. In this compound, a morpholine ring with a nitrogen atom is linked to a methyl group. N-methyl-2-morpholinone is also utilized as a solvent and intermediate in organic synthesis, showing similarities in its physical and chemical properties to 1-Methyl-2-piperidone.
