1-Methyl-1H-pyrrole-2-carboxaldehyde, a chemical compound commonly used in the synthesis of pharmaceuticals and other organic compounds, plays a vital role in various industries and research sectors. Despite its scientific nature, this compound’s relevance extends to everyday life, as it is utilized in the production of medicines, fragrances, and other consumer products. Its presence underscores the importance of organic chemistry in advancing healthcare and creating innovative products that enhance our daily experiences.
Table of Contents:
- 💡 Commercial Applications
- ⚗️ Chemical & Physical Properties
- 🏭 Production & Procurement
- ⚠️ Safety Considerations
- 🔬 Potential Research Directions
- 🧪 Related Compounds
💡 Commercial Applications
1-Methyl-1H-pyrrole-2-carboxaldehyde, commonly known as alpha-methyl pyrrolidine, has various commercial and industrial applications. It is frequently used as a building block in the synthesis of pharmaceuticals, agrochemicals, and fragrances. This compound is also utilized in the production of flavors and fragrances for consumer goods.
In the realm of drug and medication applications, 1-Methyl-1H-pyrrole-2-carboxaldehyde plays a crucial role. It serves as an intermediate in the synthesis of various drugs, including antiviral, antibacterial, and antifungal agents. Additionally, this compound is utilized in the creation of pharmaceuticals for the treatment of neurological disorders and mood-related conditions.
In the pharmaceutical industry, 1-Methyl-1H-pyrrole-2-carboxaldehyde is integral in the development of novel medications. Its versatility and efficacy as a building block make it a valuable component in drug synthesis. Moreover, this compound’s stability and reactivity contribute to its widespread use in drug discovery and development processes.
⚗️ Chemical & Physical Properties
1-Methyl-1H-pyrrole-2-carboxaldehyde appears as a colorless liquid with a pungent, sweet odor.
The molar mass of 1-Methyl-1H-pyrrole-2-carboxaldehyde is approximately 109.13 g/mol, and its density is around 1.09 g/cm³. In comparison, common food items such as sugar (molar mass around 342.3 g/mol, density around 1.59 g/cm³) and salt (molar mass around 58.44 g/mol, density around 2.16 g/cm³) have higher molar masses and densities.
1-Methyl-1H-pyrrole-2-carboxaldehyde has a melting point of -54 °C and a boiling point of 189 °C. In contrast, common food items like butter (melting point around 32-35 °C, boiling point above 200 °C) and chocolate (melting point around 30-32 °C, boiling point above 200 °C) have higher melting and boiling points.
1-Methyl-1H-pyrrole-2-carboxaldehyde is slightly soluble in water and has a low viscosity. This differs from common food items such as sugar and salt, which are highly soluble in water and have higher viscosities.
🏭 Production & Procurement
In the production of 1-Methyl-1H-pyrrole-2-carboxaldehyde, commonly known as N-methylpyrrole-2-carboxaldehyde, a key step involves the reaction of 1-methylpyrrole with an appropriate aldehyde source, such as formaldehyde, in the presence of a suitable acid catalyst. This reaction leads to the formation of the desired product, which can then be isolated and purified through various extraction and distillation processes.
1-Methyl-1H-pyrrole-2-carboxaldehyde can be commercially procured from chemical suppliers specializing in fine chemicals and intermediates. The compound is typically available in varying purities, ranging from technical grade to high purity grades suitable for pharmaceutical use. Upon procurement, the compound is usually packaged in sealed containers to prevent contamination or degradation during transportation.
For transportation purposes, 1-Methyl-1H-pyrrole-2-carboxaldehyde is typically handled in accordance with established regulations governing the transportation of hazardous materials. The compound may be shipped in bulk quantities or as smaller packaged units, depending on the requirements of the end user. Proper labeling and documentation are essential to ensure safe handling and transportation of the compound to its intended destination.
⚠️ Safety Considerations
Safety considerations for 1-Methyl-1H-pyrrole-2-carboxaldehyde include the potential for skin and eye irritation upon contact. It is advised to handle this chemical in a well-ventilated area to mitigate inhalation risks. Additionally, precautions should be taken to avoid ingestion and prolonged exposure to this compound.
The hazard statements for 1-Methyl-1H-pyrrole-2-carboxaldehyde include “Causes skin and eye irritation” and “May cause respiratory irritation.” These statements indicate the potential risks associated with contact and inhalation of this chemical. It is important to handle this substance with caution and use appropriate personal protective equipment to prevent any adverse effects.
Precautionary statements for 1-Methyl-1H-pyrrole-2-carboxaldehyde include “Wear protective gloves/eye protection/face protection” and “IF INHALED: Remove person to fresh air and keep comfortable for breathing.” These statements emphasize the importance of using safety equipment when handling this chemical and the proper response in case of exposure. It is crucial to follow these precautions to minimize the risks associated with this compound.
🔬 Potential Research Directions
One potential research direction for 1-Methyl-1H-pyrrole-2-carboxaldehyde could be exploring its potential applications in organic synthesis, particularly in the development of new pharmaceuticals or agrochemicals. Researchers may investigate the reactivity of this compound in various chemical reactions to determine its potential utility in producing complex organic molecules.
Additionally, studies could focus on the biological activity of 1-Methyl-1H-pyrrole-2-carboxaldehyde, including its potential as a drug lead compound. Testing its efficacy against different biological targets or diseases may provide valuable insights into its pharmacological potential and pave the way for future drug discovery efforts.
Furthermore, investigations into the synthesis of novel derivatives or analogs of 1-Methyl-1H-pyrrole-2-carboxaldehyde could be a fruitful research direction. By modifying its chemical structure, researchers may be able to enhance its biological activity, improve its stability, or alter its pharmacokinetic properties, ultimately leading to the development of more effective compounds for various applications.
🧪 Related Compounds
One similar compound to 1-Methyl-1H-pyrrole-2-carboxaldehyde is 1-Methyl-2-oxo-1,2-dihydropyrrole-2-carbaldehyde. This compound shares a similar molecular structure with 1-Methyl-1H-pyrrole-2-carboxaldehyde, differing only in the presence of an additional carbonyl group. This compound may exhibit similar chemical reactivity and properties due to the shared pyrrole ring structure.
Another similar compound to 1-Methyl-1H-pyrrole-2-carboxaldehyde is 1-Methyl-1H-pyrrole-2-carboxylic acid. This compound differs from 1-Methyl-1H-pyrrole-2-carboxaldehyde by the presence of a carboxylic acid functional group instead of an aldehyde group. Despite this difference, the two compounds share a common pyrrole ring structure, which may lead to similarities in chemical behavior and reactivity.
A further similar compound to 1-Methyl-1H-pyrrole-2-carboxaldehyde is 1-Methyl-1H-pyrrole-2-carbonitrile. This compound bears resemblance to 1-Methyl-1H-pyrrole-2-carboxaldehyde due to the presence of a nitrile functional group in place of the aldehyde group. The shared pyrrole ring structure between these compounds may result in comparable physical and chemical properties, despite differences in functional groups.
